Gelatinases A and B Are Up-Regulated in Rat Lungs by Subacute Hyperoxia

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Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia: pathogenetic implications.

Subacute hyperoxia may cause basement membrane disruption and subsequent fibrosis. To test the role of extracellular matrix degradation in hyperoxic damage, we analyzed the expression of gelatinases A and B and tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 in rats exposed to 85% O2. Oxygen-exposed rats were studied at 1, 3, 5, and 7 days, and compared with air-breathing rats. Lung...

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ژورنال

عنوان ژورنال: The American Journal of Pathology

سال: 1998

ISSN: 0002-9440

DOI: 10.1016/s0002-9440(10)65625-8